Comming Soon

Comming Soon

Comming Soon

Background:<br/>Hyperpigmentation is a common dermatological concern that manifests as darkened patches of skin caused by the overproduction of melanin. It can result from a variety of causes including sun exposure, hormonal changes, inflammation, and post-inflammatory hyperpigmentation (PIH). Accelerated and targeted management strategies are critical for enhancing patient outcomes, particularly in individuals seeking rapid improvements in skin tone uniformity.<br/>Objective:<br/>This presentation discusses the use of a novel topical agent (Lorient Elements) applied with the help of microneedling, to shorten the treatment time and maximize efficacy in treating hyperpigmentation.<br/>Methods:<br/>A sample of 6 patients, skin types 1-6, with varying degrees of hyperpigmentation were treated using a protocol of 2-3 microneedling sessions with topical application of Lorient Elements over a 4-6week period. Outcomes were assessed using the Visia Skin Analysis and patient related satisfaction scores.<br/>Results:<br/>Patients undergoing the Lorient Elements therapy protocol demonstrated significant objective reduction in hyperpigmentation assessed using the Canfield Visia Skin analysis. After 2-3 treatments over a 4-6 week period, patients reported high satisfaction, with 100% noting visible improvement in skin tone within the first 4 weeks. Adverse effects were minimal, primarily mild transient post-procedural erythema.<br/>Conclusion:<br/>Accelerated management of hyperpigmentation utilizing Lorient Elements with microneedling can significantly reduce treatment times and enhance patient outcomes. The integration of this topical agent with procedural intervention provides a comprehensive and effective approach to treating hyperpigmentation.

Background. Laser-Assisted Drug Delivery (LADD) enhances the penetration of pharmaceuticals and cosmeceuticals through the skin. Recently, laser-assisted delivery of weakly cross-linked hyaluronic acid (HA) and minimal invasive treatments has gained popularity, but its efficacy is primarily based on clinical evaluations.<br/>Objective. This study aims to monitor and assess the impact of HA on living human skin after non-ablative fractional laser (NAFL) treatment.<br/>Methods. Four areas on the forearms of healthy male and female subjects were marked, and each area was assigned to either (i) NAFL + HA, (ii) NAFL monotherapy, (iii) topical HA monotherapy, or (iv) untreated control. NAFL treatment was administered using a 1927 nm thulium laser. Evaluations were conducted 30 minutes and 30 days post-treatment using multiphoton tomography with fluorescence lifetime imaging (MPT-FLIM).<br/>Results. Eleven subjects participated. HA was distinguishable from surrounding tissue through a very short fluorescence lifetime. After NAFL treatment, HA was present throughout all epidermal and upper dermal layers, while in intact skin, HA was primarily only in the superficial layers with lower concentrations. Mean fluorescence lifetimes indicated that the HA gel supported the wound healing process post-laser treatment.<br/>Conclusion. LADD effectively improves HA penetration through the skin, enhancing hydration and providing long-term rejuvenation benefits. It is a valuable alternative to injection of HA. MPT-FLIM is an effective diagnostic tool for monitoring drug delivery and evaluating treatment responses, enabling tailored therapy adjustments.