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Background and Objectives: A threshold fluence for melanosome disruption has the potential to provide a robust numerical indicator for establishing clinical endpoints for the treatment of pigmented lesions with picosecond laser. Although the thresholds for 755-nm picosecond laser were reported, the wavelength dependence has not been investigated. In this study, wavelength-dependent threshold fluences for melanosome disruption are determined. Using a mathematical model based on the thresholds, irradiation parameters for 532-, 730-, 755-, 785-, and 1064-nm picosecond laser treatments are evaluated quantitatively.<br/>Study Design/Materials and Methods: The suspension of melanosomes extracted from porcine eyes was irradiated with picosecond lasers with varying fluence. The mean particle size of the irradiated melanosomes was measured by dynamic light scattering and their disruption was observed by scanning electron microscopy to determine the disruption thresholds. A mathematical model was developed combined with the threshold obtained and Monte Carlo light transport to calculate irradiation parameters required to disrupt melanosomes within the skin tissue.<br/>Results: The threshold fluences were determined to be 0.95, 2.25, 2.75, and 6.5 J/cm² for 532-, 730-, 785-, and 1064-nm picosecond lasers, respectively. The numerical results quantitatively revealed the relationship between irradiation wavelength, incident fluence, and spot size required to disrupt melanosomes distributed at different depths in the skin tissue. The calculated irradiation parameters are consistent with clinical parameters that showed high efficacy with a low incidence of complications.<br/>Conclusion: The wavelength-dependent thresholds for melanosome disruption were determined. The results of evaluation of irradiation parameters from the threshold-based analysis provide numerical indicators for setting the clinical endpoints for 532-, 730-, 755-, 785-, and 1064-nm picosecond lasers.

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Recent advancements in picosecond laser technology, innovative DOE fractionated beam handpieces, and evolving treatment protocols have enabled us to offer completely non-invasive pico laser rejuvenation treatments with minimal to no downtime. These treatments now deliver clinical results that are increasingly comparable to traditionally aggressive procedures. This presentation showcases the latest developments and refinements in our cutting-edge Pico Sculpting treatments, featuring LASEROPTEK Co. Ltd.’s PicoLO Premium picosecond Nd:YAG laser and the unique Dia FX 1064 and Dia FX 532 handpieces. We will review long-term case outcomes and introduce newly optimized protocols, including the combined use of fractionated 1064 nm and 532 nm wavelengths in a single session.

Acne scars pose a significant challenge in dermatology, affecting patients’ self-esteem. This presentation examines the use of picosecond laser therapy as an adjunct treatment for acne scar revision, particularly in combination with modalities such as chemical peels, microneedling, and fillers. Picosecond lasers deliver energy in short pulses, enhancing collagen remodeling and improving skin texture with minimal damage. When paired with complementary treatments, results can be significantly enhanced. For instance, combining picosecond laser with microneedling increases the efficacy of topical agents, while chemical peels address pigmentation issues. Clinical protocols, case studies, and patient outcomes will be discussed, highlighting the benefits and potential complications of this multifaceted approach. A personalized treatment plan is essential for achieving optimal results.