Session
- Title : Hair Restoration
- DermaV Room : Level 2, Geumgang Hall, Avenue
- Time : 09:00 - 10:30
Chair
Gwang Seong Choi South Korea
Gulhima Arora India
Lecture & Speaker
| Hours | Speakers | Title |
|---|---|---|
| 09:00 - 09:15 | Smriti Shrestha | Changing donor dominance in hair transplant with trichoscopy of 100 cases The concept of hair transplant is based on the theory of donor dominance postulated by Dr Norman in 1957 and the concept of "safe donor zone" calculated by many ace hair transplant surgeons time and again. However, as the hair loss becomes an epidemic, both of these are being challenged in recent times. <br/>The issues of synchronization of the hair cycle, donor miniaturization, oxidizing scalp lipids, changes in scalp microbiome, global rise in environmental pollution, metal and chemical exposure, lifestyles, hair chemicals, etc are changing our donor zone like never before. Men with androgenetic alopecia are thronging hair clinics in large numbers. <br/>During Trichoscopy, we observed that majority of men visiting us with androgenetic alopecia did not match the safe donor zone or donor dominance. We observed that miniaturization of the donor hairs is very common. Our findings were increased vellus or miniaturized hairs in donor zone, single hairs, empty follicles, perifollicular erythema, peripilar cast, hair pin vessels etc in the donor zone. Hence we conclude that trichoscopy a must tool before undergoing hair transplant as it can predict the longevity of transplanted follicles, their fate in the long run, as well as help us plan better about preserving the existing hairs as well as the transplanted hairs. |
| 09:15 - 09:30 | Aseem Sharma | Platelet rich plasma - does it work and what does evidence say? Platelet-Rich Plasma (PRP) therapy has gained widespread popularity in dermatology, particularly in the treatment of various types of alopecia. Despite its increasing use, questions regarding its efficacy and clinical evidence remain central to ongoing debates within the dermatological community. PRP, an autologous concentration of platelets in plasma, is rich in growth factors that theoretically stimulate hair follicle regeneration, improve hair density, and slow the progression of hair loss.<br/><br/>This lecture will examine the underlying mechanism of PRP in hair restoration, with a focus on its effects on the dermal papilla cells, hair follicle stem cells, and the angiogenic factors involved in hair growth. We will explore the different types of alopecia where PRP has been investigated, including androgenetic alopecia, alopecia areata, and other less common forms of hair loss.<br/><br/>Key clinical studies and evidence will be reviewed to assess the effectiveness of PRP in improving hair density, thickness, and overall scalp health. The discussion will include an analysis of clinical outcomes, patient selection, and the optimal protocols for PRP preparation, including variations in platelet concentration, activation methods, and injection techniques. We will also address conflicting data in the literature, highlighting the need for standardization in PRP therapy.<br/><br/>Safety, side effects, and patient satisfaction will be discussed, particularly in relation to long-term follow-up and recurrence of hair loss after PRP therapy. Comparative effectiveness with other hair restoration treatments, such as oral medications, topical agents, and surgical options, will also be evaluated to position PRP within the broader therapeutic landscape for alopecia.<br/><br/>In conclusion, PRP offers a promising, minimally invasive option for hair restoration, but its success depends on proper patient selection, technique, and adherence to evidence-based protocols. The lecture will aim to provide a balanced view of PRP’s role in alopecia management, grounded in the latest clinical evidence and practical insights from current research. |
| 09:30 - 09:45 | Gulhima Arora | Harnessing adult multipotent stem cells for hair regeneration Dr. Gulhima Arora<br/>Mehektagul Dermaclinic<br/>New Delhi, India<br/><br/>The present treatments for androgenetic alopecia only target limited pathways of the different mechanisms of action of the condition known till date. The clinical outcomes with the many existing medical and procedural modalities for restoring hair are far from predictable and satisfactory. Present treatments need long-term commitments and sessions leading to compliance issues and have inherent side-effects. Most of them only repair, rather than cure.<br/><br/>Extending the therapeutic armamentarium involves the novel use of cell-based therapies. These are treatments with powerful regenerative potential, moving from repair to cure. Adult multipotent stem cells, though, having limited potential for differentiation, are being used with promising clinical outcomes for disorders related to the hair follicle, with a lot of published literature coming to light. They act by paracrine signaling to stimulate or restore the progenitor cell pool around the hair follicle. These have proved useful as hair restoration treatments beyond the existing ones as they are capable to targeting the entire niche around the hair follicle. They can be minimally manipulated and without being chemically spiked or cultured by just using washing filtering and centrifugation techniques. This makes them fall legally into the purview of treatments that are allowed to be done in point-of care clinics, without having to be part of a clinical trial as is a prerequisite in many countries. Another advantage is they are mostly used as autologous treatments and the downstream effects are more predictable. <br/><br/>These cells can be harvested form the fat, blood or skin with great accessibility, though they are present in all organs. They may be those of hemopoietic or mesenchymal origin, with the latter having more potency. The use of Adipose Derived Stem Cells (ADSC) in the prepared micro fragmented adipose tissue and the stromal vascular fraction (SVF) have gained a position of high repute in the treatment of androgenetic alopecia. |
| 09:45 - 10:00 | Ruri Diah Pamela | Scientific advances in hair boosters: the science and practice Recent scientific advances in hair boosters have revolutionized the approach to hair restoration and enhancement, combining innovative biotechnological methods with clinical practices. This review explores the latest developments in hair boosters, including novel formulations, delivery systems, and bioactive compounds such as growth factors, peptides, and plant-derived stem cells, platelet-rich plasma, etc which have shown promising results in stimulating hair growth and improving hair quality. We examine the underlying mechanisms by which these agents promote hair follicle activity, extend the anagen phase, and enhance scalp health. Additionally, the integration of these hair boosters with advanced techniques like microneedling, laser therapy, and personalized treatment plans is discussed, highlighting their efficacy and potential in clinical practice. As the demand for non-invasive and effective solutions to hair loss and thinning continues to grow, these scientific advances provide a comprehensive understanding of their mechanisms, benefits, and practical applications in dermatology and aesthetics. |
| 10:00 - 10:15 | Suparuj Lueangarun | Exosomes in hair regrowth and repigmentation Exosomes, particularly those derived from mesenchymal stem cells (MSCs), have shown promising potential in promoting hair regrowth and repigmentation. These nano-sized extracellular vesicles contain surface biomarkers, such as tetraspanins (CD9, CD63, CD81), and can activate key signaling pathways, including the Wnt/β-catenin pathway, which stimulates dermal papilla (DP) cell proliferation, hair follicle development, and transition from the telogen to anagen phase. Studies demonstrate that MSC-derived exosomes and other variants, such as those from colostrum, effectively promote hair regeneration in both in vitro and in vivo models, offering an alternative to treatments like minoxidil with fewer side effects.<br/><br/>Furthermore, exosome therapy combined with fractional picosecond lasers has shown significant results in hair repigmentation. This innovative approach not only addresses hair loss but also presents a potential treatment for conditions involving hair discoloration, such as poliosis.<br/><br/>The regenerative effects of exosomes extend beyond hair, with notable applications in skin health and wound healing. While exosome-based treatments are emerging as effective therapies for hair and skin conditions, further research is needed to optimize their clinical use and fully understand the underlying mechanisms involved in hair regrowth and repigmentation. |
Speaker
Smriti Shrestha
Anova Skin & Hair Clinic Nepal
Curriculum Vitae
Dr. SMRITI SHRESTHA Assistant Professor of Dermatology MBBS, MD Dermatology NMC No 8132 Hair Transplant, Antiaging & Fat Graft Surgeon Treasurer at Hair Transplant Society of Nepal (NSHSR) Kathmandu Nepal. Distinction in MD Dermatology, KU (75%). Fellowship in Aesthetic Plastic Surgery 2017 (Nanjing) Fellowship in Lasers and Cutaneous Surgery 2018 (Bangkok) Scholarship at Principles of STI/HIV in University of Washington, Seattle July 2015. Award paper winner in “Lasers in warts” in Aesthetica Asia 2016 in Kolkata, India. Author of Research Articles in PUBMED indexed National and International Journals including Skinmed and JCAD Journals. INTERNATIONAL INVITATIONS: International Chairperson and Speaker at SAARCUM (2018) International Speaker at Face Aesthetic Society of Dermatologists (FADS) India (2018, 2019) International Speaker at Stem Cell Xpress, Noida, India (2018, 2019, 2021) Invited Speaker at Trichology Meet India (2020) International Speaker at Hair Transplant Workshop by IADL India (August 2021) MEMBERSHIPS: Member of International Society of Dermatology (ISD) Member of DASIL (Dermatologic and Aesthetic Surgery International League) Member of SODVELON (Society of Dermatologists, Venereologists and Leprologists of Nepal) Member of International Trichoscopy Society (ITS) Executive member of Stem Cell Society of India (Delhi) RESEARCH ACTIVITIES: Editor at Trichology and Cosmetology Journal (India) Reviewer at Journal of Nepal Health Research Council (JNHRC) Reviewer at Clinical Case Reports (USA) Reviewer at NJDVL (Dermatology Journal Nepal) SOCIAL MEDIA CONTRIBUTION TV INTERVIEWS: 1. Nepal Television 2. NTV PLUS HD 3. Janata TV 4. Prime TV 5. APHD 1 Television 6. DC Nepal (Youtube Channel) 7. The Good Health (Youtube Channel) YOUTUBE CHANNEL: Dr Smriti Shrestha INSTAGRAM: drsmritishrestha TWITTER: Dr Smriti Shrestha, MD Website: www.anovaskin.com.np NEWSPAPER ARTICLES: 1. International: DASIL (Europe), Stem Cell Magazine of India. 2. Regular write-Ups: Nepali and English Newspapers of Nepal: The Kathmandu Post, The Medicos, Hamro Doctor, Naari, Naya Patrika, Swasthya Patrika, Ekagaj, DC Nepal, Sampurna weekly, Online khabar, etc ACADEMIC QUALIFICATIONS: Degree Institution University Percentage Year MD (Masters Degree in Dermatology) College of Medical Sciences, Bharatpur, Chitwan. Kathmandu University 75% (Distinction) 2014 MBBS Kathmandu University, Dhulikhel. KU 71% 2009 Intermediate Level (I. SC) St Xavier College, Kathmandu Tribhuvan University 72% 2001 CLINICAL SKILLS: 1. Excellent knowledge and skills in general dermatology. Updated on Latest International guidelines. 2. Cosmetology – Expertise on Botox (worked with Allergan Botox and Dysport) – Fillers (Juvederm, Restylane, Perfect HA) – PRP therapy on skin and hair (Remi 8C and Arthrex) – Chemical peels like GA, TCA, Black peel, Yellow peel, etc by mesoaesthetics, Sesderma, cosmelan etc. – Microneedling with Dermapen4 device – Hydrafacial – Eyelid surgery for Blepharochalasis 3. Hair Transplant : Doing Hair transplant since 2016. Able to perform slits, extraction and implant. Can conduct upto 4000 grafts in a day. Both FUE and DHT techniques. Also nanofat assisted hair transplant. 4. Fat Graft – Only doctor performing fat grafting in Nepal. Fat grafting done for structural volume replacement, skin rejuvenation and Hair loss. (Dr Gois kit) 5. Lasers : Have worked with Long pulsed Nd:YAG (won award), IPL, Diode, PDL lases, Ablative and Fractional CO2 and Picosec QS Nd:YaG lasers. TRAINING AND ACADEMIC PARTICIPATION 1. Fellowship Training in Aesthetic Plastic Surgery for liposuction and lipotransfer (fat graft) in Nanjing Medical University, China. 2. “Botox Hands On Training” organized by Allergan in April and August 2016. 3. Organizing Secretary of the “First Hair Restoration Workshop in Nepal” on 21 st and 22 nd April 2016. 4. Organizing Secretary of “Advanced CME on Hair Restoration and Trichoscopy Practice Management” on 21 st April 2017. 5. Scholarship at University of Washington, Seattle, USA to attend the “23 rd annual Principals of STI and HIV research training” in July 2015 with Dr King K Holmes. 6. Training at Leprosy Mission Hospital, Anandaban from 5 th Dec 2014 to 20 th Dec 2014. 7. Hands ON Workshop on Fillers in India (2017, 2018, 2019) PRESENTATIONS: 1. International Invited Faculty and Speaker at South Asian Alliance of Resistant Cutaneous Mycosis (SAARCUM) on “Whats in the Name: Antifungal resistance vs failure” in Delhi. 2. Chairperson in Lip Augmentation session at Face Aesthetic Society of Dermatologists of India (FADS). 3. International Invited Speaker at “Stem Cell Express” by Stem Cell Society of India on “Fat Graft”. 4. Award paper won at Aesthetica Asia Kolkata in Sept 2016, on "Long pulsed Nd:YaG Lasers in the management of Verruca." 5. Speaker at 2 nd International Dermatology Conferenece (ICD) in Kathmandu, Nepal. 6. Oral presentation on “Hirsutism: an approach” at XIII th National Conference of SODVELONCON-2015. 7. Oral presentation on “Efficacy of high dose short course oral steroids in the management of Toxic epidermal necrolysis” at SODVELONCON-2014. 8. Poster Presentation on “Necrobiosis lipoidica in a non-diabetic patient” at SODVELONCON-2013. 9. Poster Presentation on “Progressive Nodular Histiocytosis” at SODVELONCON-2012. 10. Webinars: IMCAS, Galderma, Threadlift, etc PUBLICATIONS: 1. Shrestha S. Lipectomy for symptomatic relief of Lymphangioma Circumscriptum. Journal of Cutaneous and Aesthetic Dermatology 2020;13:08 2. Shrestha S, Karn D, KC S, Mishra A. An unusual presentation of lepromatous leprosy as verrucous growth in the oral cavity. Lepr Rev (2017) 88, 285– 289. 3. Shrestha S. Correlation of Hormonal Profile and Lipid Levels with Female Adult Acne in a Tertiary Care Center of Nepal. Journal of Nepal Health Res Counc 2018 July; 16(2):222-227. 4. Shrestha S, Karn D. Long Pulsed Nd:YAG Lasers in the Management of Cutaneous Warts. Kathmandu Univ Medical J. 2018;61(1):60-4. 5. Shrestha, S., Karn, D., Tamrakar, D., Madhup, S., & Karmacharya, B. (2019). Profile of Clients of HIV Testing and Counseling in a Tertiary Care Center and Need of Testing in Tuberculosis. Nepal Journal of Dermatology, Venereology & Leprology, 17(1), 22-26. 6. Shrestha S, Mishra A. Actinic lichen nitidus with dermoscopic features, and response to hydroxychloroquine. Trichol Cosmetol Open J. 2019; 1(2): 11-14. 7. Shrestha A, Shrestha S. Variations of Dermatological findings in New-borns of a community hospital in Nepal. Journal of Nepal Paediatric Society. 2018;37(3):261-66. 8. Shrestha S, Aryal A. Pyoderma Gangrenosum with Positive Antinuclear Antibody, in the Absence of Systemic Association. NJDVL 2017;16(1):66-69. 9. KC S, Karn D, Shrestha S. Photo-onycholyisis Following Two Weeks Of Doxycycline. J Nepal Health Res Counc 2016 Jan - Apr;14(32):66-8. 10. Skinmed Journal. Accepted Article: Lockdown dermatoses’ during COVID-19 – A series of 127 patients from the Indian subcontinent" 11. Thesis entitled: Lichen planus and its clinico-histopathological correlation. MAGAZINES: 1. Stem cell magazine of India “Who wants to look older? No One.” 2. DASIL Newsletter of Italy, “Nepal member reports on role of radiodiagnosis in dermatology” 3. Swasthyapatrika : articles on antiaging, thyroid and skin, pollution, cosmeceuticals, etc. 4. Sampurna weekly of Annapurna Post : Fat Graft. LANGUAGES 1. Fluent in English 2. Nepali 3. Hindi REFERENCES: 1) Prof Mahesh Chandra Mathur, MD(AIIMS), DCP (UK) Head of Department, Dermatology Department College of Medical Sciences, Bharatpur, Chitwan, Nepal Email – maheshmathur2@yahoo.com Phone – 977-9804217326 2) Professor Dr Gan Shen, (MD) Head of Department & Stem Cell Expert, Plastic Surgery Department, Nanjing Medical University, Nanjing, China. Email : ganshenmd@126.com Phone: 0086-18905180338 3) Dr Roy Kim, Plastic Surgeon, San Francisco, CA, USA. Email: drkim@drkim.com Phone: 415-362-1846 4) Dr Prabhu Mishra, (Member ISCT & ISSCR) CEO & Founder of StemGenn Therapeutics, Greater Kailash, Delhi. Email: Prabhu.m@stemgenn.com Phone: 91-9810418415
Aseem Sharma
Director, Skin Saga Centre / ADMIRE Academy, Mumbai, India India
Curriculum Vitae
Dr. Aseem Sharma is the Director and Chief Dermatologist at Skin Saga Centre for Dermatology in Mumbai, as well as the Director of ADMIRE Procedural Dermatology Academy. A former Assistant Professor at LTMMC & GH Mumbai, he has served in key roles such as Maharashtra State Liaison for the World Health Organization and a Retired Squadron Leader in the Indian Air Force. With over 180 publications and five books as Chief Editor, Dr. Sharma has delivered over 1,000 presentations worldwide. He is a respected authority on PRP and regenerative dermatology and is a former journalist for the New Delhi Times.
Gulhima Arora
Mehektagul Dermaclinic India
Curriculum Vitae
Founder Director & Senior Consultant Dermatologist Mehektagul Dermaclinic New Delhi India. President Indian Association of Dermatologists Venereologists and Leprologists Delhi State Branch Associate Editor Journal of Cutaneous and Aesthetic Surgery Section Editor, Indian Dermatology Online Journal Associate Editor Cosmoderma Assistant Editor Frontiers in Medicine Coordinator Special Interest Group Aesthetics 2021-2023 Professor BN Banerjee Gold Medal for best post graduate thesis Fellowship Regenerative Medicine Honorary Fellow Philippine Academy of Clinical and Cosmetic Dermatology Publications 74 Editor-in-Chief IADVL Textbook of Acne Scar Prevention and Management Associate Editor IADVL Handbook of Aesthetics Trainer Allergan Medical Institute
Ruri Diah Pamela
Chief Department of Dermatology, Venereology & Aesthetic ,The General Soedirman National Defense Central Hospital Indonesia
Curriculum Vitae
Dr. Ruri Pamela is a highly esteemed specialist in dermatology, venereology, and aesthetics. Currently serving as the Chief of the Department of Dermatology, Venereology and Aesthetic at The General Soedirman National Defense Central Hospital in Jakarta, and co-founder of Sehati Research Institute. Dr. Pamela holds a medical degree from the Faculty of Medicine at Christian University of Indonesia and completed her residency in Dermatology and Venereology at the University of Padjadjaran. Her extensive professional memberships include the Indonesian Society of Dermatology and Venereology, the American Society for Laser Medicine and Surgery, and the Dermatologic and Aesthetic Surgery International League, among others. Dr. Pamela is a prolific contributor to national and international publications, having presented numerous case reports and research findings at various esteemed forums. Her research spans a wide range of dermatological issues, including the treatment of melasma, acne scars, and hair loss using advanced technologies such as lasers and platelet-rich plasma. Dr. Pamela has received several awards and certifications, including the L'oreal Skin and Hair Research Grant in 2022 . Her contributions to education are notable, with frequent engagements as a speaker, moderator, and trainer at both national and international conferences, where she shares her insights on innovative treatments and best practices in dermatological care.
Suparuj Lueangarun
DeMed Clinic Center Thailand
Curriculum Vitae
Dr. Suparuj Lueangarun is an Assistant Professor specializing in dermatologic surgery at DeMed Clinic Skin Center and Department of Aesthetic Medicine, College of Integrative Medicine, Dhurakij Pundit University, Bangkok and Thailand. He excels in procedural dermatology, dermatologic surgery, and addressing concerns such as acne scars, hypertrophic scars, keloids, and hair loss. Dr. Lueangarun’s achievements encompass esteemed honors and awards, including ASIA PACIFIC LA FONDATION LA ROCHE-POSAY Clinical Research Grants, the Eli Lilly & HCP Scholarship Awards for the European Academy of Dermatology Congress, DASIL research award and the World Congress for Hair Research award. His research covers a wide range of topics including acne scars, keloid, melasma, alopecia, and laser treatments. To get in touch, reach out via email: dr.suparuj@gmail.com.